Spider-Man/Deadpool, Issue #6 is a "guest issue," written by Scott Aukerman and penciled by Reilly Brown. I didn't know Aukerman did comics, but I caught myself laughing on the first page and gave it a shot. I laughed on the second page and really liked the detail throughout the comic. There are references to Hyperion, Captain America, and a host of other recent storylines.
In short, the pages flew by. The story of this issue, which is unrelated to the rest of the series, is that they're going to make a movie about Deadpool. Hmm... I wonder where they got that idea? Anyway, long story short. Don't skip this issue.